The analysis involved a rigorous methodology to ensure the reliability of these findings:
the specific genes affected within those 122,348 regions? Find the original article for more detailed methodology? 122348
The study identified these 122,348 genomic regions as having significantly different methylation patterns (adding or removing methyl groups, which changes gene expression) between various colorectal adenoma (precancerous polyp) subtypes and normal tissue. 122,348. Hypermethylated regions (Gene silencing): 6,263. Hypomethylated regions (Gene activation): 116,050. The analysis involved a rigorous methodology to ensure
Colorectal Adenoma Subtypes Exhibit Signature Molecular Profiles 348. Hypermethylated regions (Gene silencing): 6
These DMRs suggest that DNA methylation changes are a crucial, early event in colorectal tumorigenesis, acting before severe morphological changes occur in the cells.