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Because its levels fluctuate heavily depending on the presence of tumors, tracking miR-140 expression quantities in tissue is actively researched as a way to predict clinical outcomes and survival rates in patients with neoplasia.

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In many malignancies—including breast, lung, prostate, and gastrointestinal cancers—miR-140 is significantly downregulated. It typically acts as a tumor suppressor by inhibiting cell proliferation, invasion, and metastasis while encouraging cell death (apoptosis). Because its levels fluctuate heavily depending on the

Do you need focus on its impact or its oncology/cancer impact? It typically acts as a tumor suppressor by

A clinical review published on PubMed demonstrates that miR-140 heavily dictates how sensitive cancer cells are to chemotherapy drugs like doxorubicin, cisplatin, and temozolomide. Up-regulating its expression can actively enhance the efficacy of these treatments.

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