Targeted deletion of Interleukin-3 results in asthma exacerbations
The report examines the role of and its receptor in childhood asthma. The image likely refers to data panels within Figure 1 or Figure 2 of the study, which show: 2348-set-1x.jpg
: The study concludes that IL-3 is not just a byproduct of inflammation but plays a role in the resolution of asthma; its absence (targeted deletion) leads to worse exacerbations. Scientific Context The full technical report and all associated data
The research cites foundational work on murine helper T cell clones to define lymphokine activities, specifically noting that IL-3 is released by activated T cells. The full technical report and all associated data figures can be accessed through the Cell Press/iScience portal. 2348-set-1x.jpg
: Higher expression of the IL3Ra mRNA was identified in asthmatic children, particularly those with a forced expiratory volume (FEV1%) higher than 80%.
: A significant increase in IL-3 secretion was found in the peripheral blood mononuclear cells (PBMCs) of children with asthma compared to healthy controls.