Pyruvate Dehydrogenase Kinase 4 (PDK4/PD4K) is a critical mitochondrial enzyme that acts as a metabolic switch regulating energy use in tissues. It plays a role in disease, acting as a tumor suppressor in some cancers while influencing insulin resistance and preventing ferroptosis. For further research, see PMC and PubMed studies.
Validation and the role of PDK4 relevant to ferroptosis ... - PMC