[s4e16] House's Head (part 2) -

: The recovered memory reveals that House, too drunk to drive, called Wilson for a ride; Amber arrived instead. They were on the bus together when the accident occurred. The Medical and Moral Failure

: The finale fundamentally alters the series' core relationship. Wilson is left alone, finding a final note from Amber, while House awakens from a coma to face the wreckage of his friendship. [S4E16] House's Head (Part 2)

In the second part, "Wilson's Heart," the team discovers Amber is suffering from multisystem organ failure. : The recovered memory reveals that House, too

: House is motivated by an unfamiliar sense of guilt. He ponders the unfairness of a "misanthropic drug addict" surviving while a promising young physician dies. Wilson is left alone, finding a final note

: House deduces that Amber was taking amantadine for the flu. The crash caused acute kidney failure, preventing her body from processing the drug and resulting in lethal amantadine poisoning.

: The episode concludes with Thirteen testing positive for Huntington’s disease, echoing the theme that life is often "unfair" and beyond a doctor's control.