: As a wedding gift, Derek gives Meredith her first solo surgery—a successful colon surgery overseen by Richard Webber.
: George O'Malley faces an emotional crisis when almost all the students from the accident die under his care, leaving him devastated until Owen Hunt helps him see the lives he did save. [S5E22] What a Difference a Day Makes
: Rhimes described the episode as the moment Meredith evolved from a "dark and twisty" girl into an "extraordinary" woman capable of choosing happiness. : As a wedding gift, Derek gives Meredith
: To promote the 100th episode, ABC created a real wedding website for Meredith and Derek that fans could actually visit and RSVP to. : To promote the 100th episode, ABC created
: Jeffrey Dean Morgan makes a final appearance as Denny Duquette, appearing as a hallucination to Izzie that Derek and Bailey eventually realize is a symptom of her worsening condition. Behind the Scenes Facts