Often referred to as tissue transglutaminase, TG2 is a multifunctional, Ca²⁺-dependent protein that acts far beyond a simple crosslinker. It’s an enzyme that wears many hats:
Because TG2 is implicated in chronic conditions like cancer and neurodegeneration (such as Huntington's and Alzheimer's), it is now a hot target for new therapeutic drugs designed to selectively inhibit its activity without harming healthy cells.
TG2 acts as a "molecular glue," crosslinking extracellular collagen and fibronectin to help stabilize tissue structure, making it vital for wound healing. Often referred to as tissue transglutaminase, TG2 is
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Inside the cell, TG2 contributes to survival pathways. However, its dysregulation is linked to celiac disease, fibrosis, and tumor progression, making it a critical player in disease research.
When things go wrong, TG2 shifts roles. In the extracellular space, it binds to integrins and acts as a co-receptor, facilitating cell adhesion and migration. However, its dysregulation is linked to celiac disease,
Based on your request, "TG2" most commonly refers to , a crucial enzyme in human biology, or Technical Grade 2 (TG2) , which is a frequently mentioned technical exam, particularly for positions like Technician Electrical in the Uttar Pradesh Power Corporation Limited (UPPCL).