It tethers vesicles to the plasma membrane, facilitating sound encoding.
The protein utilizes several C2 domains (C2A-C2F) to bind Ca 2+raised to the 2 plus power and lipids, as shown in the protein structure below. 2. C2 Domains: Function & Interactions tm,cc,jp
Sensing: The C2D domain is identified as critical, as disruptions in this area alter synaptic sound encoding. It tethers vesicles to the plasma membrane, facilitating
Based on the 2025 research regarding the protein , which is crucial for hearing and synaptic transmission, C2 Domains: Function & Interactions Sensing: The C2D
Binding Sites: High-resolution structures revealed that multiple Ca 2+raised to the 2 plus power
Lack of functional otoferlin or its C2 domain interaction prevents proper vesicle docking, leading to profound deafness. Summary Table: Otoferlin C2 Interactions Function/Location C2B-C2G Main interface for membrane binding C2D Crucial Ca 2+raised to the 2 plus power binding site; mutations affect sound encoding C2F-C2G Rearrange upon membrane binding to close structure Target Membrane Membrane where vesicles are docked
Upon binding, a "closed" conformation is adopted, where C-terminal domains (C2F, C2G) rearrange. 3. Key Findings in Synaptic Transmission Ca 2+raised to the 2 plus power